Patients with musculoskeletal pain experience symptomatic improvements and few side effects following the sustained use of medical cannabis, according to data published in the scientific journal Cureus in early May, 2025.
Investigators affiliated with the Rothman Orthopaedic Institute at Thomas Jefferson University in Philadelphia USA assessed the safety and efficacy of long-term cannabis use in a cohort of 129 patients suffering from musculoskeletal pain. Study participants were registered in Pennsylvania’s medical cannabis access program and were assessed for at least one year. Over three-quarters of study subjects reported using at least one type of cannabis product daily, with most (64%) choosing to use topical formulations.
Consistent with prior studies, the majority (93%) of pain patients said that cannabis improved their primary symptoms. Cognitive and motor effects were minimal for most users, with 72% reporting “no impact” on their thinking, coordination, or motor functions. Some 40% of study participants acknowledged reducing their use of traditional analgesics, including opioids, following medical cannabis initiation—a finding that is also consistent with other studies.
“Long-term MC (medical cannabis) use is a stable and well-tolerated option for managing chronic musculoskeletal pain, with high patient-reported efficacy and minimal cognitive impact” the study’s authors concluded. “These findings support its role in pain management”.
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23 May, 2025