Cannabinoids in Treating Chemotherapy-Induced Nausea and Vomiting, Cancer-Associated Pain, and Tumour Growth
September 2024
Researchers have been particularly interested in the potential uses of cannabinoids in treating cancer due to their ability to regulate cancer-related cell cycle pathways, prompting many beneficial effects, such as tumour growth prevention, cell cycle obstruction and cell death. Cannabinoids have been found to affect tumours of the brain, prostate, colon and rectum, breast, uterus, cervix, thyroid, skin, pancreas and lymph.
School of Medicine, Stanford University, Palo Alto, California, USA
Cannabinoids and Triple Negative Breast Cancer Treatment
August 2024
Triple-negative breast cancer (TNBC) accounts for about 10-20% of all breast cancer cases and is associated with an unfavourable prognosis. Cannabinoids show anti-tumour activity in most pre clinical studies in TNBC models and do not appear to have adverse effects on chemotherapy.
Institute of Oncology Ljubljana and the University of Ljubljana, Ljubljana, Slovenia.
Cannabinoids in the Treatment of Glioblastoma
March 2024
Glioblastoma (GBM) is the most prevalent primary malignant tumour of the nervous system. While the treatment of other neoplasms is increasingly more efficacious the median survival rate of GBM patients remains low, about 14 months. Due to this fact, there are intensive efforts to find drugs that would help combat GBM.
Cannabinoids are becoming more and more important in the field of cancer and not only because of their antiemetic properties during chemotherapy. These compounds may have a direct cytotoxic effect on cancer cells. Through cannabinoid receptors 1 and 2 (CB1R and CB2R) cannabinoids inhibit the proliferation and invasion of GBM cells, along with changing their morphology. Cannabinoids also induce an intrinsic pathway of apoptosis (a type of programmed cell death) in the tumour.
Department of Experimental and Clinical Physiology, Centre for Preclinical Research, Medical University of Warsaw, Poland
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